Background of bacterial genome editing

•    Colibactin is a genotoxin synthesized by Escherichia coli that induces DNA damage that can lead to gene mutations, chromosomal instability, and senescence.
•    Colibactin-producing E. coli strains are associated with cancerous and precancerous colorectal tissues and are suspected of promoting colorectal carcinogenesis
•    Polyamines are highly abundant in cancer tissue