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In the ongoing struggle against infectious diseases, the demand for translationally relevant preclinical models has never been greater. The advent of humanized mouse models—engineered to carry functional human genes, tissues, or immune systems—has fundamentally transformed the way we investigate pathogen biology and host responses.

In the realm of animal models used for studying infectious diseases, the mouse has established itself as a methodological standard ........ yet, at the heart of these studies, a discreet but powerful molecule can undermine results: ....

Vibiosphen’s constant objective is to develop innovative and translational experimental models that would ultimately result in the decrease of the number of animals used for preclinical testings.

Organoids are miniaturized in vitro organ models that are derived from stem cells. They can be established from two sources of cells: adult stem cells (ASCs) or induced pluripotent stem cells (iPSCs). The organoids are formed by generating 3D aggregate through the cell culture.

A valid animal model of SARS-CoV-2 infection and its complications might shed light on the pathophysiology of the disease and can be used for assessing the efficacy and safety of novel antiviral compounds.

At Vibiosphen, we reproduced a mouse model of SARS-CoV-2 infection [1] and modified it to better define key post-infection immunological abnormalities. For this purpose, 7-week-old transgenic (K18-hACE2)2Prlmn male mice were intranasally challenged with a lethal dose (200 PFU/mouse) of SARS-CoV-2 (Wuhan strain).