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Bacteria rely on a system called quorum sensing (QS) to sense population density and make collective decisions.

The 6M € granted to IN-ARMOR project will optimize an already developed drug platform using Computer Aided Drug Design. 

By zooming in the mechanism that bacteria use to escape the antibiotics, we find three different subgroups – resistance – tolerance – persistence.

Distinguishing these three groups is key in the fight against bacterial infection.

A collaboration between 3 players : L’oréal – Qima – Vibiosphen

Our last collaboration led to a great publication to understand the aetiology of dandruff, and specifically the role of Malassezia restricta.

Acne vulgaris is a common inflammatory disorder affecting more than 80% of young adolescents. Cutibacterium acnes plays a role in the pathogenesis of acne lesions, although the mechanisms are poorly understood. 

Recent advances in sequencing technology have demonstrated that the development of AD not only associates with the skin microbiome, but also with gut microbiota. In other words, unbalanced gut microbiome or intestinal permeability may lead to a loss of integrity of the skin barrier that might trigger predispositions to atopic dermatitis in this case.

The silent pandemic threat is now well known in the field of infectious disease, but yet still few new antimicrobials are coming on the market. Even if a recent study showed that in 2019, 1,2 Million death was due to resistant bacterial infections and thus more death was attributed to bacterial infection than HIV or Malaria.

The emergence of bacterial pathogens with acquired resistance to almost all available antimicrobials is one of the major concerns today. Resistant pathogens are causing 700,000 deaths per year. It is expected by 2050 that infectious diseases will be responsible for more than 10 million deaths per year, a number higher than the 8.2 million caused by cancer today.