Assessment of the cytotoxic and anti-infective activity of compounds using human lung organoid models
Human and animal health In vitro/ex vivo cytotoxicity
Background of in vitro 3D organoid model development
Cell culture remains a cornerstone of preclinical drug development, particularly in infectious diseases and respiratory research. Historically, two-dimensional (2D) cell culture systems have been widely used due to their simplicity and scalability. However, these models fail to reproduce the architectural complexity, cellular heterogeneity, and physiological responses of native human tissues.